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KMID : 1103920040100020142
Korean Journal of Hepatology
2004 Volume.10 No. 2 p.142 ~ p.147
A Case of Combined Hepatocellular-Cholangiocarcinoma with Sarcomatous Transformation and Second Primary Colon Cancer
±èÀçÈñ/Kim JH
À̿뱸/ÀÌÁØ/Á¤Ã¶±Ç/±èÇüÅÂ/°­ÇýÀ±/°í±¤Çö/È«¼ºÇ¥/Ȳ¼º±Ô/¹ÚÇÊ¿ø/ÀÓ±Ô¼º/Lee YG/Lee J/Jung CK/Kim HT/Kang H/Kho KH/Hong SP/Hwang SG/Park PW/Rim GS
Abstract
Combined hepatocellular-cholangiocarcinoma is a rare form of primary liver cancer, featuring both hepatocellular and biliary epithelial differentiations. An intrahepatic tumor may be considered as a metastatic lesion. It has been suggested in the literature that the likelihood of metastasis in the cirrhotic liver is lower than that in the non-cirrhotic liver. A rare case of combined hepatocellular-cholangiocarcinoma and second primary colon adenocarcinoma in a 67-year-old male patient with liver cirrhosis is presented. Histologically, the intrahepatic mass was composed of a spindle cell sarcomatous component; a hepatocellular carcinoma component; and a cholangiocarcinoma component. There were focal transitional regions among the different components. Immunohistochemically, the cholangiocarcinoma component of the intrahepatic mass showed positive reactions for CK-7 but negative reactions for CK-20. The adenocarcinoma of the colon showed positive reactions for CK-20 but negative reactions for CK-7.
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